Statins are usually taken before going to sleep. This is because the hepatic synthetic activity is maximum at night. Hence statins have maximum efficiency in decreasing cholesterol when given at night. This is especially important in statins with short half life such as simvastatin. Newer statins like atorvastatin have a longer half life.
Other drugs which block the hepatic synthetic function (eg: warfarin which blocks hepatic synthesis of clotting factors) are also best given at night time.

Warfarin exerts its anticoagulant action by interfering with the vitamin K mediated synthesis of clotting factors in the liver. Hepatic synthetic function is maximum at night. So warfarin has maximum action when it is given at night. Other drugs which block the hepatic synthetic function (eg: statins are used to block cholesterol synthesis) are also best given at night time.

Digoxin has a long half life. Hence to prevent cumulative toxicity, it is given for 5 days every week. The next course of digoxin is started after a gap of 2 days. Because of its peculiar dosage schedule, it is easy to ask for intake of digoxin by carefully taking the treatment history.

Phaeochromocytoma
Hyperthyroidism
Hypothyroidism
Hyperaldosteronism (Conn’s syndrome)
Cushing’s syndrome
Acromegaly
Hyperparathyroidism

Sham rage is seen in
a) Decerebrate animals
b) Decorticate animals
c) Hypothalamic lesions