Amoxycillin is an extended spectrum aminopenicillin. But it is not active against penicillinase producing organism. Clavulanic acid is a penicillinase inhibitor which initially reversibly and then irreversibly inhibits penicillinase 2-5 except cephalosporinase. So this drug combination has a synergistic action.

1. Pharmacology – MCQ 85 – Mycophenolate mofetil
2. Pharmacology – MCQ 124 – Drug interaction – ranitidine and sucralfate
3. Pharmacology – MCQ 19 – All of the following antiepileptic agents act via Na+ channel except?
4. Sulfonylureas