Allergic mediators released from mast cells
3 September 2010
Antigens can cause degranulation of mast cells resulting in allergic reactions. Some of the allergic mediators released from mast cells are preformed whereas others are synthesised on demand.
| Preformed mediators | |
|---|---|
| ECF-A | Eosinophil chemotactic factor of Anaphylaxis – attracts eosinophils to the site |
| NCF – A | Neutrophil chemotactic factor – attracts neutrophils to the site |
| Histamine | Vasodilation and bronchospasm |
| Heparin | Promotes phagocytosis |
| Newly synthesised mediators | |
| Prostaglandin | Vasoconstriction and bronchospasm |
| Leukotriene | Vasoconstriction and bronchospasm |
| Thromboxane A2 | Vasoconstriction and platelet aggregation |
| PAF | Platelet Activating Factor – bronchospasm, platelet aggregation, chemotaxis of neutrophils, eosinophils |
| TNF alpha | Tumour necrosis factor – transmigration of eosinophils and neutrophils |
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