Pharmacology – MCQ 12 – The following drugs are used in obesity except?

The following drugs are used in obesity except?
A. Orlistat
B. Sibutaramine
C. Olestra
D. Neuropeptide Y Agonist

Correct answer : D. Neuropeptide Y Agonist

Older antiobesity drugs act by inhibiting noradrenaline or serotonin reuptake. Newer ones have various mechanisms.

  • Older generation agents
    • Noradrenergic agents (influence appetite center)
      • Phentermine
      • Mazindol
    • Serotonergic agents (influence satiety center)
      • Fenfluramine
      • Dexenfluramine
    • Noradrenergic / Serotonergic agents (combined action)
      • Sibutramine
  • Newer agents
    • Orlistat – Inhibits gastric and pancreatic lipase – digestion and absorption of triglycerides is impaired
    • Olestra – Suprose polyester which can replace fat as a cooking medium
    • Leptin analogues
    • Neuropeptide Y antagonist
    • Beta 3 adrenergic agonists
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