Disulfiram causes an acute reaction following intake of alcohol and is used for treatment of alcoholism (deterrent therapy). Some drugs produce disulfiram like reactions and hence should be avoided in patients who consume alcohol. Or the patient should stop alcohol consumption..

Metranidazole
Cephalosporins
Chlorpropamide
Furazolidine
Griseofulvin
Citrated calcium carbamide

Certain drugs inhibit theophylline metabolism, thus increasing blood levels and cause toxicity:

Ciprofloxacin
Cimetidine
Erythromycin
Allopurinol
Oral contraceptives

Some others increase theophylline metabolism, decreasing blood levels:

Phenobarbitone
Phenytoin
Rifampicin

Smoking and consumption of charcoal boiled meat also increase theophylline metabolism.

Questions summary:

All of the following are non selective beta blockers with additional actions except?
All of the following may be associated with beta 2 agonist treatment except?
True statement about clonidine are all except,
Finasteride is a:
Which of the following is not an alkylating agent?
Which of the following is a prodrug
All of the following are Gp IIb/Illa antagonist except?
Orange coloured urine is due to:
The drug having maximum propensity to cause peripheral neuropathy?
Nesiritide is a:

Powerpoint presentation summary:

General considerations

Statistics
Important things to remember

Aspirin

Indications
Clinical presentation in aspirin overdose
Complications
Management of salicylism

Paracetamol

Clinical presentation
Use of IV N-acetylcysteine

Carbon monoxide

Mechanism of hypoxia
Use of hyperbaric oxygen in management

Cocaine poisoning
Opiates
3,4-methylenedioxy-methamphetamine - MDMA (Ecstasy)

Author : Kevin O’Shaughnessy
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Anticoagulants, Antiplatelet drugs and Thrombolytic agents – Presentation Summary

Major classes of drugs
Platelet Activation
Aspirin
Newer antiplatelets – Thienopyridines
CAPRIE trial
CURE trial
MATCH trial
Glycoprotein IIb/IIIa antagonists
Fibrinogenesis
Heparin – Mechanism of action
Features of Low Molecular Weight Heparin
LMWH vs Unfractionated heparin
Warfarin
Pharmacokinetics of warfarin
Drugs interactions of Warfarin
Warfarin toxicity treatment
Fibrinolysis
Tissue plasminogen activator vs streptokinase
Beyond LMWH
Ximelagatran

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Pharmacology of acute poisoning – Powerpoint Summary

General considerations
History
Investigations
Management

Decreasing poison absorption
Increasing poison elimination

Paracetamol – overdose and management
Aspirin – overdose and management
Tri cyclic antidepressants - overdose and management
Benzodiazepine - overdose and management
Poisoning by other drugs

Author : Dr Ian Wilkinson
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Teriparatide is a recombinant form of PTH that is used in patients with osteoporosis
The usual drugs used in osteoporosis are anti resorptive agents
But teriparatide has a unique mechanism of action
Endogenous PTH induces bone demineralisation
But intermittent pulses of exogenous PTH stimulates osteoblastic activity (Teriparatide is given once daily)
Teriparatide stimulates new bone formation – adds bone to periosteal surface and increases trabecular bone volume and connectivity

Reference:
Osteoporosis: a guide for clinicians By Pauline M. Camacho, Paul Miller

The most important adverse effect of thalidomide is teratogenicity. The others include:

Peripheral neuropathy
Deep vein thrombosis
Constipation
Rash
Fatigue
Hypothyroidism

Reference:
Basic and Clinical Pharmacology, Katzung, 10th edition, p919

Renal clearance of lithium is decreased by about 25% in those who take diuretics, hence dosage should be adjusted
Similar effect is also noted in certain newer NSAID’s
Neuroleptics (other than clozapine and newer antipsychotics) when given with lithium produce increased extra pyramidal side effects

Reference:
Basic and Clinical Pharmacology, Katzung, 10th edition, p471

SERCA stands for:

Smooth Endoplasmic Reticulum Calcium Aptase (involved in sequestration of calcium for later release)