Sclerostin – Medicine MCQ

Sclerostin is produced by?
A. Osteocytes
B. Osteoblasts
C. Osteoclasts
D. Chondrocytes

Correct answer : A. Osteocytes

Sclerostin (SOST) is a glycoprotein produced by osteocytes.
They also synthesize receptor activator of nuclear factor kappa B ligand (RANKL).
Both of these are involved in regulating bone formation and resorption.

Ref: Davidson’s Principles and Practice of Medicine, 22nd Edition, p1061
Additional reading: http://en.wikipedia.org/wiki/Sclerostin

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