True regarding Okazaki fragment – Biochemistry MCQ

Which of the following is true regarding Okazaki fragment?
A. Are segments of RNA attached to an RNA initiator component
B. Are related to the leading strand
C. Several Okazaki fragments must be sequentially synthesized for each replication fork
D. Helicase acts on the leading strand to unwind dsDNA

Correct answer : C. Several Okazaki fragments must be sequentially synthesized for each replication fork

dna replication

  • Okazaki fragments are segments of DNA attached to an RNA initiator component.
  • They are related to the lagging strand.
  • Helicase acts on the lagging strand to unwind dsDNA.

Ref: Harper’s Illustrated Biochemistry, 27th edition, p335, 336.
Image credits:  Author: Boumphreyfr. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://en.wikipedia.org/wiki/File:RNA_primer.png

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