Agents which decrease bone resorption in osteoporosis – Orthopaedics MCQ

Agents which decrease bone resorption in osteoporosis are all except?

A. Risedronate
B. Teriparatide
C. Strontium ranelate
D. Raloxifene

Correct answer : B. Teriparatide

X-ray spine – lateral view – showing osteoporotic wedge fractures of  vertebrae – L1 & L2

Drugs used for treatment of osteoporosis

• Drugs which reduce bone resorption (anti resorptive drugs)
  • Selective estrogen receptor modulators – Raloxifene
  • Bisphosphonates – Etidronate, Risedronate, Pamidronate, Alendronate
  • Hormone replacement therapy / estrogen
  • Calcitonin
  • Calcium supplements
  • Vitamin D
  • Denosumab -Monoclonal antibody which inhibits the maturation of osteoclasts by binding to and inhibiting RANKL.
• Drugs which increase bone formation
  • Teriparatide
• Drugs with both effects (decreases bone resorption and increases bone formation)
  • Strontium ranelate