Agents which decrease bone resorption in osteoporosis – Orthopaedics MCQ

Agents which decrease bone resorption in osteoporosis are all except?

A. Risedronate
B. Teriparatide
C. Strontium ranelate
D. Raloxifene

Correct answer : B. Teriparatide

osteoporotic fracture

X-ray spine – lateral view – showing osteoporotic wedge fractures of  vertebrae – L1 & L2

Drugs used for treatment of osteoporosis

  • Drugs which reduce bone resorption (anti resorptive drugs)
    • Selective estrogen receptor modulators – Raloxifene
    • Bisphosphonates – Etidronate, Risedronate, Pamidronate, Alendronate
    • Hormone replacement therapy / estrogen
    • Calcitonin
    • Calcium supplements
    • Vitamin D
    • Denosumab -Monoclonal antibody which inhibits the maturation of osteoclasts by binding to and inhibiting RANKL.
  • Drugs which increase bone formation
    • Teriparatide
  • Drugs with both effects (decreases bone resorption and increases bone formation)
    • Strontium ranelate

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