A lady on long term hemodialysis developed carpel tunnel syndrome. The cause was diagnosed to be amyloidosis by using a biopsy. What is the type of amyloid that is seen?
A. Beta 2 microglobulin
B. Amyloid light chain
D. Amyloid associated protein
Duodenum with amyloid deposition in lamina propria. Amyloid is seen as a homogenous pink material in lamina propria and around blood vessels. (20x magnification)
Beta 2 microglobulin is a part of MHC class I molecule.
Correct answer : A. Beta 2 microglobulin
Explanation : Patients undergoing long term hemodialysis develop amlyloidosis due to deposition of Beta 2 microglobulin. These deposits are seen in the synovium, joints and tendon sheaths.
Image credits – Wikipedia