AIIMS November 2011 – MCQ 185

A lady on long term hemodialysis developed carpel tunnel syndrome. The cause was diagnosed to be amyloidosis by using a biopsy. What is the type of amyloid that is seen?

A. Beta 2 microglobulin
B. Amyloid light chain
C. ATTR
D. Amyloid associated protein

Duodenum with amyloid deposition in lamina propria. Amyloid is seen as a homogenous pink material in lamina propria and around blood vessels. (20x magnification)

Beta 2 microglobulin is a part of MHC class I molecule.

Correct answer : A. Beta 2 microglobulin
Ref: Robbins
Explanation : Patients undergoing long term hemodialysis develop amlyloidosis due to deposition of Beta 2 microglobulin. These deposits are seen in the synovium, joints and tendon sheaths.

Related mnemonics:
Causes of Carpal tunnel syndrome
Causes of secondary amyloidosis

Image credits – Wikipedia