AIIMS November 2011 – MCQ 199
All true about pancreatitis excpt
A. Drotrecogin alfa used when apache score > 25
B. ?
C. ?
D. ?
If you know the complete question, please post them below as a comment. Thanks!
2 Comments
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Recombinant human activated protein C (also called drotrecogin alfa) promotes fibrinolysis and inhibits thrombosis. It was hypothesized that rhAPC may benefit patients with sepsis because it modulates the procoagulant response that is believed to contribute to multisystem organ dysfunction. This hypothesis was initially tested in the PROWESS trial, which reported that rhAPC improved 28-day mortality in patients with severe sepsis or septic shock, with its greatest benefit among patients with a high risk of death (ie, APACHE II score ≥25). However, conflicting data from subsequent studies eventually led to a new trial, the PROWESS-SHOCK trial. In this trial, 1696 patients with vasopressor-dependent septic shock were randomly assigned to receive rhAPC or placebo. Preliminary analyses done by the maker of the drug indicated that rhAPC did not improve 28-day mortality.
Uptodate.com
Thus this choice seems to be wrong. Let us know about other choices
Option D is It is not used in sepsis