AIIMS November 2011 – MCQ 47

Which among the following is true regarding octreotide?
A. Stimulates growth hormone
B. Used in secretory diarrhoea
C. Given orally
D. Contraindicated in acromegaly

Molecular structure of octreotide

(Modified repeat question – AIPGME 07 MK q86 – All are true regarding octreotide except? )

Correct answer : B. Used in secretory diarrhoea

Ref:  KDT 5th, p217, SRB 3rd, p618

Explanation:

• Octreotide is a synthetic analog of somatostatin
• Inhibits secretion of : Growth hormone, Pancreatic polypeptide, VIP, 5-HT, Gastrin, Glucagon, Insulin and Cholecystokinin.
• It was first synthesized in 1979
• It is given parenterally – subcutaneous / intravenous / intramuscular – not given orally
• Dose: 50 microgram as loading dose IV, 50 microgram 1 hour in 5% dextrose as maintenance dose
  

• In hormone secreting tumours – acromegaly, carcinoid syndrome, glucoganoma, gastrinoma, WDHA (watery diarrhea, hypokalemia, and achlorhydria)
• Secretory diarrhoea due to carcinoid, short bowel syndrome, AIDS, diabetes (reduces fluid secretion, slows intestinal motility)
• GI fistula, pancreatic fistulas
• Variceal bleeding
• Dumping syndrome
• Pancreatic surgeries
• Acute pancreatitis