AIIMS November 2011 – MCQ 73

All of the following are criteria for primary hyperaldosteronism except?
A. Diastolic hypertension without edema
B. Metabolic acidosis present
C. Low secretion of rennin
D. High secretion of aldosterone inspite of reduced volume of fluid

Correct answer : B. Metabolic acidosis present

Ref: Harrison 18th ed
Excess activation of the mineralocorticoid receptor leads to potassium depletion and increased sodium retention, with the latter causing an expansion of extracellular and plasma volume. Increased ENaC activity also results in hydrogen depletion that can cause metabolic alkalosis.