All are true regarding leflunomide except? – Pharmacology MCQ

All are true regarding leflunomide except?
A. Inhibits proliferation of stimulated lymphocytes
B. Depresses antibody production by B lymphocytes
C. Can be used in children
D. Can cause thrombocytopenia

Correct answer : C. Can be used in children

Conversion of leflunomide into its active metabolite

• Leflunomide is an immunomodulator.
• It is used in patients with active rheumatoid arthritis.
• It inhibits proliferation of stimulated lymphocytes.
• The active metabolite of leflunomide inhibits dihydroorotate dehydrogenase and pyrimidine synthesis.
• It can depress the antibody production by B cells.
• It should not be used in children and pregnant / lactating women.

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p212.
Image credits:  Vaccinationist.  https://en.wikipedia.org/wiki/File:Activation_of_leflunomide.svg