Causes of high anion gap metabolic acidosis

The main causes of high anion gap metabolic acidosis are:

  • Lactic acidosis
  • Renal failure
  • Ketoacidosis (alcoholic / starvation / diabetes)
  • Toxin induced (ethylene glycol / methanol / salicylates)

Anion gap is the difference between measured cations and the measured anions – represents the quantity of unmeasured anions in the plasma.

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