Decreased energy production in thiamine deficiency – Biochemistry MCQ

Decreased energy production in thiamine deficiency is due to?
A. It is a cofactor for oxidative reduction
B. It is required for transamination reactions
C. It is a coenzyme for alpha ketoglutarate dehydrogenase and pyruvate dehydrogenase in citric acid cycle
D. It is a coenzyme for transketolase in hexose monophosphate shunt

Correct answer : C. It is a coenzyme for alpha ketoglutarate dehydrogenase and pyruvate dehydrogenase in citric acid cycle

A patient suffering from beriberiA patient suffering from beriberi

Thiamine – Properties, Functions and Deficiency disorders

  • Thiamine (vitamin B1) is a water soluble vitamin
  • Thiamine pyrophosphate acts as a coenzyme in the catabolism of carbohydrates and amino acids
  • It is also required for the biosynthesis of acetylcholine and gamma aminobutyric acid (GABA)
  • Cereals are the important dietary sources of thiamine
  • It is present in yeast extract and pork in very high concentrations
  • It is important for energy production as it is a coenzyme for pyruvate dehydrogenase and alpha ketoglutarate dehydrogenase in citric acid cycle (Krebs cycle / Tricarboxylic acid cycle)
  • It is a also a coenzyme for transketolase in pentose phosphate pathway (involved in the production of NADPH)
  • Deficiency of thiamine leads to Beriberi
  • The major forms of beriberi are:
    • Wet beriberi (cardiovascular disease)
    • Dry beriberi (neurological disease)
    • Infantile beriberi
  • Alcoholics are prone to develop Wernicke’s encephalopathy due to deficiency of thiamine

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