Drug interactions of lithium

  • Renal clearance of lithium is decreased by about 25% in those who take diuretics, hence dosage should be adjusted
  • Similar effect is also noted in certain newer NSAID’s
  • Neuroleptics (other than clozapine and newer antipsychotics) when given with lithium produce increased extra pyramidal side effects

Basic and Clinical Pharmacology, Katzung, 10th edition, p471

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