The enzyme catalyzing the production of orotidylic acid is?
A. Dihydro orotase
B. Aspartyl transcarbamoylase
C. Dihydro orotate dehydrogenase
D. Orotate phosphoribosyl transferase
Correct answer : D. Orotate phosphoribosyl transferase
- In the de novo synthesis of pyrimidines, the enzyme aspartyl transcarbamoylase catalyses the combination of carbamoyl phosphate and aspartate to form carbamoyl aspartate.
- Dihydro orotase catalyses the production of dihydro orotic acid.
- Dihydro orotate dehydrogenase catalyses the production of orotic acid from dihydro orotic acid.
- Orotate phosphoribosyl transferase is the enzyme catalyzing the synthesis of orotidylic acid (Orotidine 5′-monophosphate).
Ref: Textbook of Biochemistry, D. M. Vasudevan & Sreekumari S, 4th edition, page 394.