Enzyme catalyzing the production of orotidylic acid – Biochemistry MCQ

The enzyme catalyzing the production of orotidylic acid is?
A. Dihydro orotase
B. Aspartyl transcarbamoylase
C. Dihydro orotate dehydrogenase
D. Orotate phosphoribosyl transferase

Correct answer : D. Orotate phosphoribosyl transferase

  • In the de novo synthesis of pyrimidines, the enzyme aspartyl transcarbamoylase catalyses the combination of carbamoyl phosphate and aspartate to form carbamoyl aspartate.
  • Dihydro orotase catalyses the production of dihydro orotic acid.
  • Dihydro orotate dehydrogenase catalyses the production of orotic acid from dihydro orotic acid.
  • Orotate phosphoribosyl transferase is the enzyme catalyzing the synthesis of orotidylic acid (Orotidine 5′-monophosphate).

Ref: Textbook of Biochemistry, D. M. Vasudevan & Sreekumari S, 4th edition, page 394.

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