Factors increasing bone resorption – Medicine MCQ

Which of the following increases bone resorption?
A. Osteoprotegerin (OPG)
B. Oestrogen / testosterone
C. Mechanical loading
D. Interleukin 1

Correct answer : D. Interleukin 1

• Interleukin 1 stimulates bone resorption and inhibits bone formation.
• Osteoprotegerin is glycoprotein which acts as a decoy receptor for receptor activator of nuclear factor kappa B ligand (RANKL).
• It prevents RANKL induced osteoclastic bone resorption. It is produced by osteoblasts.
• Oestrogen, testosterone and mechanical loading inhibit bone resorption and stimulate bone formation.

Ref: Davidson’s Principles and Practice of Medicine, 22nd Edition, p1062