Features of multiple myeloma – Medicine MCQ

Which among the following statements is wrong :
A. Light chains are synthesised in slight excess normally in plasma cells
B. Qualitative assessment of M component can be done by electrophoresis
C. M components are detected in chronic myeloid leukaemia
D. In 20% myelomas, only light chains are produced

Correct answer: B

Plasmacytoma – H&E Stain

• Qualitative assessment of M component is done by immune electrophoresis.
• Electrophoresis is used for quantitative assessment of M component.
• M component can also be detected in other lymphoid malignancies, CML, Can breast, colon cancer , non neoplastic condition like cirrhosis, sarcoidosis, rheumatoid arthritis, myasthenia gravis.

Ref : Harrison’s Principles of Internal Medicine, 19th Edition, p 710-712.
Image credits: Nephron. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://en.wikipedia.org/wiki/File:Plasmacytoma_ultramini1.jpg