Collection of Medicine MCQs (Cardiovascular system) for medical students. Concept based MCQs with detailed explanations which help students to gain valuable insights and gain an edge in competitive examinations. More than just answering MCQs, the explanations will improve the knowledge and understanding about the conditions discussed. Also useful for MD students who are preparing for Superspeciality entrance examinations. Medicine MCQs - Cardiovascular System Kindle Edition: Click Here for a Preview. Comments and suggestions are most welcome.

Linezolid is an oxazolidinone antimicrobial agent. It is a bacteriostatic agent.

Spectrum of action

MRSA (Methicillin resistant Staphylococcus areus), some VRSA (Vancomycin resistant Staphylococcus areus), VRE (Vancomycin resistant enterococci), Streptococcus pyogenes, S. viridans, S. pneumoniae, Clostridia, Mycobacterium tuberculosis, Listeria.

Mechanism of action

It binds to the 23S fraction of the 50S subunit of the bacterial ribosome. It prevents the formation of N-formyl methionine tRNA – 70S ribosome complex, thus preventing protein synthesis. Since the drug has a different site of action, it does not have cross resistance with other antimicrobial agents.


It is well absorbed orally.


Linezolid should not be used for simple infections to prevent development of resistance. It is used for severe hospital acquired pneumonias, wound infections by MRSA, VRSA, and in febrile neutropenia.

It is not useful for treatment of enterococcal bacterial endocarditis as it is only bacteriostatic.


600 mg twice daily, oral or intravenous.

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