Machado Joseph disease – Neurology MCQ

Machado Joseph disease is also known as?
A. Spinocerebellar ataxia type 1
B. Spinocerebellar ataxia type 2
C. Spinocerebellar ataxia type 3
D. Spinocerebellar ataxia type 4

Correct answer: C. Spinocerebellar ataxia type 3

Explanation:

• Machado Joseph disease is also known as Spinocerebellar ataxia type 3.
• It is the most common autosomal dominant ataxia.
• This is further classified into 3 types
  • Type 1 MJD – amyotrophic lateral sclerosis, parkinsonism – dystonia type
  • Type 2 MJD – most common form of MJD which is ataxia type
  • Type 3 MJD – ataxic amyotrophic type

Reference: Harrison’s Principles of Internal Medicine, 19th edition, p2628