Pharmacology – MCQ 131 – Dose reduction in low creatinine clearance

Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
A. Ciprofloxacin
B. Trovafloxacin
C. Lomefloxacin
D. Sparfloxacin

Correct answer : B. Trovafloxacin

Fluoroquinolones that are excreted mainly by non renal mechanisms:

  • Pefloxacin
  • Trovafloxacin
  • Grepofloxacin
  • Nalidixic acid

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