Shortest acting non-benzodiazepine hypnotic – Pharmacology MCQ

Shortest acting non benzodiazepine hypnotic is?
A. Zaleplon
B. Zolpidem
C. Zopiclone
D. Eszopiclone

Correct answer : A. Zaleplon

Zaleplon is the shortest acting non benzodiazepine hypnotic.
It has selective action on benzodiazepine receptors containing alpha 1 subunit.
It has rapid hepatic clearance with a half life of one hour.
Morning sedation is absent due to shortness of action.

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p406, 407.

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