Shortest acting non benzodiazepine hypnotic is?
Correct answer : A. Zaleplon
- Zaleplon is the shortest acting non benzodiazepine hypnotic.
- It has selective action on benzodiazepine receptors containing alpha 1 subunit.
- It has rapid hepatic clearance with a half life of one hour.
- Morning sedation is absent due to shortness of action.
Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p406, 407.