Teriparatide – Mechanism of action

  • Teriparatide is a recombinant form of PTH that is used in patients with osteoporosis
  • The usual drugs used in osteoporosis are anti resorptive agents
  • But teriparatide has a unique mechanism of action
  • Endogenous PTH induces bone demineralisation
  • But intermittent pulses of exogenous PTH stimulates osteoblastic activity (Teriparatide is given once daily)
  • Teriparatide stimulates new bone formation – adds bone to periosteal surface and increases trabecular bone volume and connectivity

Reference:
Osteoporosis: a guide for clinicians By Pauline M. Camacho, Paul Miller

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