The antiretroviral drug combination to be avoided is? – Pharmacology MCQ

The antiretroviral drug combination to be avoided is?
A. Zidovudine + Stavudine
B. Zidovudine + Lamivudine
C. Didanosine + Abacavir
D. Didanosine + Zidovudine

Correct answer : A. Zidovudine + Stavudine

• The combination of Zidovudine with Stavudine has pharmacodynamic antagonism and hence should be avoided.
• Other antiretroviral drug combinations to be avoided are:
  • Stavudine + Didanosine – Increased toxicity (neuropathy and lactic acidosis)
  • Lamivudine + Didanosine – No additive action seen

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p814.