The antiretroviral drug combination to be avoided is? – Pharmacology MCQ

The antiretroviral drug combination to be avoided is?
A. Zidovudine + Stavudine
B. Zidovudine + Lamivudine
C. Didanosine + Abacavir
D. Didanosine + Zidovudine

Correct answer : A. Zidovudine + Stavudine

  • The combination of Zidovudine with Stavudine has pharmacodynamic antagonism and hence should be avoided.
  • Other antiretroviral drug combinations to be avoided are:
    • Stavudine + Didanosine – Increased toxicity (neuropathy and lactic acidosis)
    • Lamivudine + Didanosine – No additive action seen

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p814.

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