The mechanism of action of everolimus is? – Surgery MCQ

The mechanism of action of everolimus is?
A. Blocks IL-2 gene transcription
B. Blocks IL-2 receptor signal transduction
C. Blockade of T cells
D. Prevents lymphocyte proliferation

Correct answer : B. Blocks IL-2 receptor signal transduction

Everolimus – molecular structure

• Everolimus is an immunosuppressive agent used in organ transplantation.
• It acts by blocking IL-2 receptor signal transduction.
• It inhibits an intracellular kinase called mammalian target of rapamycin (mTOR).
• This in turn interferes with intracellular signalling from the IL-2 receptor and arrest T cell division in the G1 phase.

Ref: Bailey and Love’s Short Practice of Surgery, 25th edition, p 1413-1415.
Image credits: Fvasconcellos. https://en.wikipedia.org/wiki/File:Everolimus.svg