It is loop diuretic acting on Na+ K+ 2Cl- Co-transporter in thick ascending limb of loop of Henle.

Torsemide vs Frusemide

  • 3 times more potent
  • better oral bioavailability
  • absorbed more rapidly when given orally
  • longer T1/2 (3.5 hrs)
  • longer duration of action (4-8 hrs)


  • Edema
  • Hypertension


  • 2.5-5mg OD in hypertension
  • 5-20mg/day in edema
  • upto 100mg BD in renal failure

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It is a loop diuretic causing diuresis by acting on the Na+ K+ 2Cl- cotransporters in the thick ascending limb...