Which of the following is true regarding Maraviroc?
A. Not active orally
B. Bind to transmembrane glycoprotein
C. Targets the CXCR4 receptor
D. Impairs immune surveillance
Correct answer : D. Impairs immune surveillance
- Maraviroc is a CCR5 receptor inhibitor.
- It interferes with the attachment of HIV virus to the host cell.
- It has no effect on the strains of HIV which are tropic for CXCR4 receptor.
- It is given orally.
- Impaired immune surveillance can result due to blocking of human chemokine receptor CCR5.
Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p811.
Image credits: US National Institutes of Health. https://en.wikipedia.org/wiki/File:HIV_attachment.gif (edited)