Deficiency of argininosuccinate synthase – Biochemistry MCQ

Deficiency of argininosuccinate synthase causes?
A. Hyperargininemia
B. Hyperammonemia type II
C. Argininosuccinicaciduria
D. Citrullinemia

Correct answer : D. Citrullinemia

• Argininosuccinicaciduria is caused by metabolic defect in argininosuccinase.
• Hyperammonemia type II is due to defect in ornithine transcarbamoylase.
• Hyperargininemia is an autosomal recessive disorder characterised by defect in the gene for arginase.

Ref: Harper’s Illustrated Biochemistry, 27th edition, p252.