AIIMS May 2012 – MCQ 7
Mechanism of development of edema in nephrotic syndrome is?
A. Sodium and water retention
B. Loss of proteins
C. Hyperlipidemia
D. Increased venous pressure
Correct answer : B. Loss of proteins
(Repeat AIIMS Nov 2010)
Explanation: In nephrotic syndrome, there is loss of proteins through the glomeruli. This results in hypoalbuminemia and decreased plasma oncotic pressure. Thus fluid moves into the extravascular compartment – development of edema.