AIIMS November 2011 – MCQ 151
Which of the following is the newest direct thrombin ihbibitor?
A. Ximelagatran
B. Danaparenaux
C. ?
D. ?
Please contribute to the discussion by posting the answer with references and pointing out the errors in the question!
5 Comments
Ximelagatran, an oral direct thrombin inhibitor with a rapid onset of action and predictable antithrombotic effect, has the potential to be a simple therapeutic alternative to current standard treatment of acute venous thromboembolism.
Oral ximelagatran administered in a fixed dose without coagulation monitoring, was as effective as enoxaparin/warfarin for treatment of deep vein thrombosis with or without pulmonary embolism and showed similar, low rates of bleeding. Increased levels of liver enzymes in 9.6% of ximelagatran-treated patients require regular monitoring..
http://jama.ama-assn.org/content/293/6/681.full
Danaparenaux- Could not find any drug with similar name??? but form the suffix of “parenaux” which seems too close to “parinux” it look like it is a FACTOR XA INHIBITOR. The newest in this class is Rivaroxaban.
one option was dabigatran
Actual question is- which of the fallowning is a oral direct thrombin inhibitor used in strok.
Its ximelagatran
c)dabagatran