AIIMS November 2011 – MCQ 168
In acute inflammation due to the retraction of endothelial cell cytoskeleton, which of the following results
A. Delayed transient increase in permeability
B. Early transient increase
C. Delayed permanent increase
D. Early permanent increase
(Modified repeat question – AIIMS Nov 06 – q93)
4 Comments
it was retraction of endothelial cells not contraction
yes it was retraction nd ans is delayed transient increse
Q: In acute inflammation, cytokine mediated retraction of endothelial cytoskeleton leads to:
Ans: Delayed transient permeability Ref Robbins
Endothelial cell contraction leading to intercellular gaps in postcapillary venules is the most common cause of increased vascular permeability. It is a reversible process elicited by histamine, bradykinin, leukotrienes, and many other chemical mediators. Endothelial cell contraction occurs rapidly after binding of mediators to specific receptors, is usually short-lived (15-30 minutes), and is called the immediate transient response. A slower and more prolonged retraction of endothelial cells, resulting from changes in the cytoskeleton, may be induced by cytokines such as tumor necrosis factor (TNF) and interleukin-1 (IL-1). This reaction may take 4 to 6 hours to develop after the initial trigger and persist for 24 hours or more.
answer is early transient . its a repeat from November 2006.