AIIMS November 2011 – MCQ 195
Major factor determining the rate of gluconeogeneis in liver is?
A. Alanine
B. Level of essential fatty acid in liver
C. ADP in liver
D. ?
Please contribute to the discussion by posting the answer with references and pointing out the errors in the question!
4 Comments
Alanine is an inhibitor of pyruvate kinase which is involved in Glycogenolysis, glycolysis, and pyruvate oxidation.
Level of fatty acids in the liver is importatn for the function of of Pyruvate dehydrogenase involved with glycogenolysis, glycolysis, and pyruvate oxidation.
ADP is an importatn inhibitor of Pyruvate carboxylase involved with gluconeogenesis, thus I think it should be ADP.
Harpers biochemistry.
4th option was level of cGMP in muscle
Lehninger 4th edition Page 558
Pyruvate carboxylase is stimulated by acetyl-CoA,
increasing the rate of gluconeogenesis when the
cell has adequate supplies of other substrates
(fatty acids) for energy production
Ans must be b
ques. was prolonged fasting major determinant of rate of gluconeogenesis
here rate is determined by blood level of alanine which is reduced so is d rate if iv alanine is given rate increaes rapidly. so it now depends on free fatty acids and more specifically glycerol availbility and not on esential fatty acid in liver so ans may b A. alnine
ref:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535723/pdf/jcinvest00209-0174.pdf
also note initial transient rise in alanine blood levels is due to increased release of peripheral protien stores of amino acids so ans to that question may b increased muscle break down