AIIMS November 2011 – MCQ 78

Mechanism of action of efavirenz is?
A. Inhibition of HIV 1 protease
B. Inhibition of HIV 1 reverse transcriptase
C. Inhibition of HIV 1 integrase
D. Preventing HIV entry into cell

Correct answer : B. Inhibition of HIV 1 reverse transcriptase

Ref: KDT 6th p772
Non nucleoside reverse transcriptase inhibitors (NNRTI’s) – Nevirapine and Efavirenz – These are nucleoside unrelated compounds which directly inhibit HIV reverse transcriptase without the need for intracellular phosphorylation.

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AIIMS November 2011 – MCQ 77

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