Mechanism of action of efavirenz is?
A. Inhibition of HIV 1 protease
B. Inhibition of HIV 1 reverse transcriptase
C. Inhibition of HIV 1 integrase
D. Preventing HIV entry into cell
Correct answer : B. Inhibition of HIV 1 reverse transcriptase
Ref: KDT 6th p772
Non nucleoside reverse transcriptase inhibitors (NNRTI’s) – Nevirapine and Efavirenz – These are nucleoside unrelated compounds which directly inhibit HIV reverse transcriptase without the need for intracellular phosphorylation.