AIIMS PG Entrance May 2015 – MCQ 20 – Pain on IV injection

Which of the following anaesthetic agents cause pain on intravenous administration?
A. Propofol
B. Midazolam
C. Ketamine
D. Thiopentone

Correct answer : A. Propofol

Ampoule of propofol

Pain on intravenous administration is a problem associated with the use of propofol. It occurs due to the activation of the pain receptor TRPA1, found on sensory nerves. It can be prevented by pretreatment with lignocaine.

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