A premature infant is born with a patent ductus arteriosus. In closure can be stimulated by administration of:
a) Prostaglandin analogue
c) Anti-estrogen compounds
d) Prostaglandin inhibitors
Correct answer : d) Prostaglandin inhibitors
Normally ductus arteriosus closes soon after birth. Vasodilatory effect of prostaglandin is what maintains the patency of ductus arteriosus in intrauterine life. Hence in cases of delayed closure of ductus arteriosus, we can use prostaglandin inhibitors to induce its closure.