AIIMS PG Entrance May 2015 – MCQ 22 – Recurrent respiratory papillomatosis

Topical therapy for recurrent respiratory papillomatosis is?
A. Zinc
B. Ranitidine
C. Acyclovir
D. Cidofovir

Correct answer : D. Cidofovir

Human Papillomavirus Electron Micrograph

• Recurrent respiratory papillomatosis (also known as laryngeal papillomatosis) is a disease caused by Human Papillomavirus (HPV).
• It is characterised by warty growths in the upper respiratory tract which can cause significant airway obstruction.
•  Patients present with hoarseness of voice and breathing difficulty.
• Treatment is by removal of the tumour via surgery / carbon dioxide laser.
• It may be supplemented by intralesional injection of cidofovir in moderate to severe disease.
• Interferon therapy can also be used.