Alkalinization of urine during chemotherapy – MCQ

Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs?
A. Ara-C (Cytarabine)
B. Methotrexate
C. Cisplatin
D. Ifosfamide

Correct answer : B. Methotrexate

Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity
IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules

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