Alkalinization of urine during chemotherapy – MCQ

Collection of Medicine MCQs (Cardiovascular system) for medical students. Concept based MCQs with detailed explanations which help students to gain valuable insights and gain an edge in competitive examinations. More than just answering MCQs, the explanations will improve the knowledge and understanding about the conditions discussed. Also useful for MD students who are preparing for Superspeciality entrance examinations. Medicine MCQs - Cardiovascular System Kindle Edition: Click Here for a Preview. Comments and suggestions are most welcome.

Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs?
A. Ara-C (Cytarabine)
B. Methotrexate
C. Cisplatin
D. Ifosfamide

Correct answer : B. Methotrexate

  • Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity
  • IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules

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