Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs?
A. Ara-C (Cytarabine)
Correct answer : B. Methotrexate
- Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity
- IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules