Aprepitant – MCQ

All of the following statements about Aprepitant are true except?
A. Agonist at Neurokinin receptor (NK1)
B. Crosses blood brain barrier
C. Metabolised by CYP3A4 pathway
D. Ameliorates nausea and vomiting of chemotherapy

Correct answer : A. Agonist at Neurokinin receptor (NK1)

Aprepitant is an NK1 antagonist
It crosses blood brain barrier and blocks NK1 receptors
It has an anti emetic action and is used along with chemotherapy regimens
It is metabolised in liver via CYP3A4 pathway
It decreases metabolism of drugs metabolised by CYP3A4 pathway (can prolong prothrombin time in patients on warfarin)

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