Aprepitant – MCQ

All of the following statements about Aprepitant are true except?
A. Agonist at Neurokinin receptor (NK1)
B. Crosses blood brain barrier
C. Metabolised by CYP3A4 pathway
D. Ameliorates nausea and vomiting of chemotherapy

Correct answer : A. Agonist at Neurokinin receptor (NK1)

  • Aprepitant is an  NK1 antagonist
  • It crosses blood brain barrier and blocks NK1 receptors
  • It has an anti emetic action and is used along with chemotherapy regimens
  • It is metabolised in liver via CYP3A4 pathway
  • It decreases metabolism of drugs metabolised by CYP3A4 pathway (can prolong prothrombin time in patients on warfarin)

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