Bernard Soulier Syndrome – MCQ

False regarding Bernard Soulier Syndrome?
A. Large platelets
B. Decreased platelet count
C. Ristocetin aggregation normal
D. Platelet aggregation in response to collagen and ADP is normal

Correct answer : C. Ristocetin aggregation normal

  • In Bernard Soulier Syndrome, platelet response to ADP, collagen and Thrombin are normal.
  • But no aggregation occurs in response to Ristocetin.
  • It occurs due to defect in glycoprotein Ib – the receptor for von Willebrand factor

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