False regarding Bernard Soulier Syndrome?
A. Large platelets
B. Decreased platelet count
C. Ristocetin aggregation normal
D. Platelet aggregation in response to collagen and ADP is normal
Correct answer : C. Ristocetin aggregation normal
- In Bernard Soulier Syndrome, platelet response to ADP, collagen and Thrombin are normal.
- But no aggregation occurs in response to Ristocetin.
- It occurs due to defect in glycoprotein Ib – the receptor for von Willebrand factor