Beta blockers with first pass metabolism – Pharmacology MCQ

Which of the following does not have significant first pass metabolism?
A. Labetalol
B. Acebutolol
C. Atenolol
D. Metoprolol

Correct answer : C. Atenolol

AtenololStructure of atenolol

 

  • Atenolol is a selective beta 1 blocker.
  • The lipid solubility is low.
  • Oral absorption is incomplete.
  • First pass metabolism is not significant.
  • All other drugs mentioned have significant first pass metabolism.

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p148-151.
Image credits: https://commons.wikimedia.org/wiki/File:Atenolol.svg

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