Which of the following does not have significant first pass metabolism?
Correct answer : C. Atenolol
- Atenolol is a selective beta 1 blocker.
- The lipid solubility is low.
- Oral absorption is incomplete.
- First pass metabolism is not significant.
- All other drugs mentioned have significant first pass metabolism.
Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p148-151.
Image credits: https://commons.wikimedia.org/wiki/File:Atenolol.svg