Biochemistry – MCQ 77 – Homologous substitution for valine in hemoglobin

Which of the following can be a homologous substitution for valine in hemoglobin?
A. Isoleucine
B. Glutamic acid
C. Phenylalanine
D. Lysine

Correct answer : B. Glutamic acid

Valine can be replaced by glutamic acid, aspartic acid or alanine at position 67 of hemoglobin to produce Hb Milwaukee, Hb Bristol and Hb Sydney respectively. All of these are functionally normal hemoglobin types.

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