Capsule related antigen antibody response – Microbiology MCQ

Which of the following does not have polysaccharide capsule related antigen antibody response?

A. Haemophilus influenzae
B. Neisseria meningitidis
C. Streptococcus pneumoniae
D. Bordetella pertussis

Correct answer : D. Bordetella pertussis

Streptococcus pneumoniae
Scanning Electron Micrograph of Streptococcus pneumoniae showing polysaccharide capsule

Polysaccharide capsule related antigen antibody response

  • Polysaccharide capsule in an important virulence factor in many organisms like:
    • Haemophilus influenzae
    • Neisseria meningitidis
    • Streptococcus pneumoniae
    • Klebsiella pneumoniae
    • Salmonella typhi
  • Antibodies against the capsule protect against infection
  • The capsule can be used for producing conjugate polysaccharide vaccines (for H. influenzae, N. meningitidis and S. pneumoniae)
  • Patients with B cell dysfunction, asplenia (as in sickle cell disease / after splenectomy) and complement defects are highly susceptible to infection with encapsulated organisms
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