|Small pox||Chicken pox|
|12 days||15 days|
|Rash – sites affected||Extensor surfaces, palms, soles||Flexor surfaces, axilla|
|Rash – features||Deep seated||Superficial|
|Single stage or rash present at a time||Multiple stages of rash at the same time (pleomorphic)|
|Multilocular, umbilicated vesicles||Unilocular vesicles, classically ‘dew drop on rose petal’|
|No inflammation around rash||Zone of inflammation present around rash|
|Rash – evolution||Slow, all stages are visible||Fast evolution of rash|
|Scab formation by 10-14 days of disappearance of rash||Scab formation by 4-7 days of disappearance of rash|
|Fever||Fever subsides with development of rash,
may appear again with formation of pustules
(secondary rise of temperature)
|Fever occurs with each crop of vesicles|
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