Doxorubicin induced cardiotoxicity
- Doxorubicin is an anti cancer drug which produces cardiotoxicity as side effect
- Clinical features
- Acute presentation with hypotension, arrhythmias, bundle branch block, ST changes
- Delayed presentation with features of congestive cardiac failure
- Pathology
- Development of cardiac toxicity is due to cardiomyopathy
- Risk increases beyond doses of 550mg/m2
