Doxorubicin induced cardiotoxicity

  • Doxorubicin is an anti cancer drug which produces cardiotoxicity as side effect
  • Clinical features
    • Acute presentation with hypotension, arrhythmias, bundle branch block, ST changes
    • Delayed presentation with features of congestive cardiac failure
  • Pathology
    • Development of cardiac toxicity is due to cardiomyopathy
  • Risk increases beyond doses of 550mg/m2

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