Drug interactions of lithium
- Renal clearance of lithium is decreased by about 25% in those who take diuretics, hence dosage should be adjusted
- Similar effect is also noted in certain newer NSAID’s
- Neuroleptics (other than clozapine and newer antipsychotics) when given with lithium produce increased extra pyramidal side effects
Reference:
Basic and Clinical Pharmacology, Katzung, 10th edition, p471