Enzyme inhibition by azaserine – Biochemistry MCQ

Azaserine inhibits?
A. Glycinamide ribonucleotide synthetase
B. Glycinamide ribonucleotide transformylase
C. Formyl glycinamide ribonucleotide amidotransferase
D. Inosine monophosphate synthase

Correct answer : C. Formyl glycinamide ribonucleotide amidotransferase

AzaserineAzaserine

  • In de novo synthesis of purine nucleotides, there are 10 steps.
  • The 4th step (addition of N3) is catalysed by the enzyme Formyl glycinamide ribonucleotide amidotransferase.
  • This enzyme is inhibited by azaserine, an anticancer drug.

Ref: Textbook of Biochemistry, D. M. Vasudevan & Sreekumari S, 4th edition, page 388, 389.

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