Etiology of phocomelia – Pharmacology MCQ

Phocomelia is an adverse effect of?
A. Diethylstilbestrol
B. Thalidomide
C. Valproate
D. Progestins

Correct answer : Thalidomide

• Intake of thalidomide by pregnant women is associated with the presence of phocomelia and multiple defects of internal organs of neonates. It is a teratogenic drug and is classified under category X in the risk classification of drugs used in pregnancy.
• Diethylstilbestrol can cause vaginal clear cell adenocarcinoma in girls and young women exposed to it in utero.
• Valproate can cause spina bifida and other neural tube defects in the fetus when taken by pregnant women. It can also cause heart and limb abnormalities.
• Progestins can cause virilization of female fetuses.

Ref: KDT 7th, p89.