Evans blue in measurement of plasma volume
- Evans blue is an azo dye with high affinity for albumin
- It is used to measure plasma volume
- When evans blue is administered, it tightly binds to albumin so that it does not escape into the interstitial fluid compartment – is limited to the plasma
- By measuring the concentration of Evans blue in plasma, we can find the volume of distribution as we already know the quantity of dye administered
- Plasma volume can also be measured using Albumin labelled with radioactive iodine
